Serum Creatine Phosphokinase Activity after Intramuscular Injection: The Effect of Dose, Concentration, and Volume.
Abstract
Solutions of two compounds, pralidoxime chloride and sodium chloride, were given intramuscularly to normal human subjects. The ensuing increase in creatine phosphokinase (CPK) activity in the blood was directly related to the concentration and osmolarity of the injected solution when the volume was kept constant and was directly related to the volume when the concentration or osmolarity was constant. This suggests that the diluent may make a significant contribution to increase in CPK seen after intramuscular administration of drugs. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1974
- Accession Number
- AD0773726
Entities
People
- Andris Kaminskis
- Donald L. Culver
- Frederick R. Sidell