Renal Tubular Secretion of Pralidoxime in Man
Abstract
Pralidoxime chloride is a quaternary ammonium compound used to reactivate organophosphate-inhibited cholinesterase. The drug is rapidly cleared from the plasma by renal tubular secretion, though the mechanism has not been specifically identified. Reduction of pralidoxime clearance rates and prolongation of the biologic half-life after thiamine administration, as compared to those after para-aminohippurate (PAH) administration, suggest that pralidoxime is secreted as an organic base. Furthermore, reduced excretion of pralidoxime under conditions of both urine alkalinization and urine acidification implicate an active reabsorption of pralidoxime not heretofore described.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1974
- Accession Number
- AD0774289
Entities
People
- Frederick R. Sidell
- Richard D. Swartz