Concentrations of Ampicillin and Chloramphenicol in the Serum of Patients with Acute 'Salmonella' Enteric Fever
Abstract
Concentrations of ampicillin and chloramphenicol were measured in the serum of patients being treated for acute infections by Salmonella typhi or S. paratyphi A. Ampicillin was administered by the oral or intramuscular routes, whereas chloramphenicol was given orally daily. Ampicillin concentrations were highest one hr after initiation of intramuscular therapy and two hr after oral administration. The serum concentration of ampicillin was significantly higher when it was given intramuscularly than when it was given orally. However, serum concentrations in orally treated patients were approximately the same at one hr after the fifth dose as they were one hr after the first doze, in contrast to intramuscularly treated patients, in whom the serum concentration of ampicillin was significantly lower one hr after the fifth dose. The rates of cure, relapse, and drug treatment failure were similar for all treatment regimens, and the drug concentrations attained in serum were generally above the minimal inhibitory concentration for the infecting salmonellae.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 23, 1972
- Accession Number
- AD0774363
Entities
People
- D. C. Kent
- Isis A. Mikhail
- J. Cole Smith
- K. Sorenson
- W. R. Sanborn
Organizations
- Naval Medical Research Unit Three