A Comparative Study of Human and Monkey ('Macaca irus') Fibrinogen Degradation Products.
Abstract
Immunochemical, physical, and anticoagulant properties of human and monkey (Macaca irus) fibrinogen degradation products (FDPs) were compared by immunoelectrophoresis, Sephadex G-200 gel filtration, and anticoagulant assay. Both species demonstrated a high degree of similarity in the properties and sequence of generation of FDPs derived from in vitro plasmin digestion of highly purified fibrinogen. The results of this study should permit a closer analogy to be drawn between the pathogenic mechanisms of disseminated intravascular coagulation occurring experimentally in monkeys and clinically in humans. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 27, 1973
- Accession Number
- AD0775796
Entities
People
- Gerald J. Roth
- H. Philip Fortwengler Jr.
- James A. Eaton Jr.
- Thomas R. Poskitt
Organizations
- United States Army Medical Research Laboratory