Carbohydrate Metabolism in Response to Alterations in Pancreatic Blood Flow and Hemorrhagic Shock in the Baboon.
Abstract
Hemorrhagic shock (HS) in humans is associated with hyperglycemia and a decreased insulin response. An explanation of this is a decrease in pancreatic blood flow (DPF). An experimental model tests the hypothesis that a DPF is a major determinant of the insulin response to HS. In 18 adult male baboons, the celiac artery was cannulated. The inflow was derived from the animal's carotid artery. Celiac perfusion rates were reduced over a five-hour period. Blood samples were obtained until death from portal and peripheral veins and analyzed for glucose, insulin, growth hormone, NEFA, triglycerides, and cortisol. Arterial lactate levels were also obtained. Ten baboons received 100 gm. of exogenous glucose after cannulation. Two animals served as controls. Four animals were in non-hemorrhagic shock (NHS) with DPF and four in HS of 60 mm Hg had normal pancreatic blood flow (NPF). In eight baboons glucose was not given. Three animals were in HS with NPF and 5 had DPF without HS. The general response to HS was an elevation of blood glucose which was more marked in those baboons challenged with a glucose load. (Modified author abstract)
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 1973
- Accession Number
- AD0776247
Entities
People
- Charles T. Cloutier
- Edward B. Leeds
- Harry S. Soroff
- Phyllis A. Childs