Interaction of Rare Gases with Model Membranes and its Implication for Narcosis.
Abstract
A study is reported of the interaction of rare gases and other anesthetic agents with membranes and the findings are examined for their implication on narcosis. The report is divided into four categories: The development of an appropriate bioassay method for determining the anesthetic potency of the inert gases as well as other volatile anesthetics; the physicochemical aspects of the action of general anesthetics agents is examined on a molecular basis; some very preliminary observations on the effect of inert gases on ion transport in frog sartorius muscle; the non-applicability of the widely used INDO method to the calculation of the intermolecular energies that play such an important role in anesthesia as well as many other biological processes.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 22, 1974
- Accession Number
- AD0776648
Entities
People
- Walter S. Koski
Organizations
- Johns Hopkins University