Effects of 5-Fluorouracil on Astrocyte Density in the Rat Spinal Cord Dorsal Funiculi after Stab-Wound Lesion.
Abstract
Lesions of both groups contained moderate densities of astrocytes. The average density in the 5-FU treated group was less than that of the controls by 12.6% at the 95% confidence level; therefore, the chemotherapy reduced the cell density. Cell migration into the lesion is a possible explanation for the relatively small reduction in astrocyte density. With the present state of knowledge, 5-FU chemotherapy is not warranted to facilitate CNS 'nerve' regeneration. (Modified author abstract)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 23, 1974
- Accession Number
- AD0777016
Entities
People
- John Norman Grim
Organizations
- Northern Arizona University