Bone Marrow Response of Beagles to Fractionated Doses of Mixed Gamma-Neutron Radiation
Abstract
Male beagles were bilaterally exposed to mixed gamma-neutron radiation from the AFRRI-TRIGA reactor. The dose rate was 20 rads/minute for all irradiations and midline tissue doses were 215 rads, 225 rads and 240 rads. At each dose approximately one-half of the animals received a single irradiation while the others were given one-fourth the dose each day for 4 consecutive days. The objective of this study was to determine if doses in the median lethal range delivered in four equal fractions at 24-hour intervals were more lethal and more damaging to survival-limiting hematopoietic cell renewal systems than similar unfractionated doses. Single irradiations were the more lethal, first evident at 225 rads and increasing markedly in effectiveness at 240 rads. Radiation- induced changes in bone marrow cellularity were similar after single and fractionated irradiations. (Modified author abstract)
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1973
- Accession Number
- AD0777032
Entities
People
- F. A. Mitchell
- J. E. West
- J. Witz
- S. R. Jones
Organizations
- Armed Forces Radiobiology Research Institute