(1) Pathogenesis, Detection, Prevention and Treatment of Infectious Diseases of Military Importance. (2) Human Leukoxyte Migration Inhibition: An Assay for Endotoxemia. (3) Mechanisms of Endotoxin Tolerance. IX. Effect of Early Exchange Transfusion on Endotoxin Lethality
Abstract
The Division of Infectious Diseases of the University of Maryland School of Medicine continues to maintain a volunteer research ward at the Maryland House of Correction, Jessup, Maryland. The purpose of this facility has been to serve as a base for investigations in volunteers of various uniquely human infectious diseases. These studies have been aimed primarily at the evaluation of various vaccines. In recent years the effort has been directed at enteric infections of military importance. Quantitative measurements of effectiveness of oral typhoid and shigella vaccines have been carried out. In addition, attempts have been made to uncover the significance of pathogenesis of and host resistance to infection with the presumed viral agent of 'winter vomiting' disease, enterotoxigenic E. coli and penetrating E. coli. Availability of these human models has allowed for cooperative research projects to explore the role of endotoxin in infectious diseases, and to attempt to define mechanisms of immunity, i.e., cellular versus humoral. The status of these studies is presented in the report.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 25, 1974
- Accession Number
- AD0777539
Entities
People
- Bernard Dubuy
- Celeste L. Woodward
- Richard B. Hornick
- Sheldon E. Greisman
- Wolfe Blotzer
Organizations
- University of Maryland School of Medicine