Relationship of Chemical Structure to Pathophysiological Properties of Endotoxin from 'Serratia marcescens' 08
Abstract
Results from prior studies have implicated the lipopolysaccharide portion of the endotoxin complex as the responsible agent for pathophysiologic events. The present work was carried out to define more precisely the chemical nature of the active site of the endotoxin. Endotoxin from S. marcescens has been degraded by aqueous phenol or acetic acid hydrolysis into a number of chemically defined structural fragments. Intraveneous injections of these fragments into awake or anesthetized animals was carried out to compare their biochemical, hemodynamic and lethality relationships. Results strongly suggest that the typical pathophysiological manifestations of endotoxin shock depend on the presence of ester-linked fatty acids in the lipid moiety of the endotoxin complex.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 15, 1974
- Accession Number
- AD0777715
Entities
People
- A. Prancan
- B. Benjamin
- C. S. Want
- Lerner B. Hinshaw
- P. Alaupovic
Organizations
- University of Oklahoma Health Sciences Center