Collagenase Inhibitors in 'Pseudomonas' Keratitis. Adjuncts to Antibiotic Therapy in Rabbits
Abstract
Collagenase inhibitors as adjuncts to antibiotic therapy were evaluated in experimentally induced Pseudomonas keratitis in rabbits. Neither the combination of 1% edetic acid (EDTA) and 0.25% polymyxin B sulfate nor that of 1.2% cysteine and 0.25% polymyxin B sulfate was more effective than the polymyxin B sulfate alone. There was a small statistical difference in favor of a combination of edetic acid-cysteine-polymyxin B sulfate when it was compared with an edetic acid-polymyxin B sulfate combination. This difference, although statistically significant, did not appear to be clinically important in the treatment of the experimental model.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 1972
- Accession Number
- AD0778145
Entities
People
- Bobby L. Caraway
- George Bohigian
- Mario Valenton
- Massao Okumoto