Screening for Selective Inhibitors of the Phosphonylation of Acetylcholinesterase.
Abstract
With the object of finding prophylactic drugs to prevent organophosphorus anticholinesterase poisoning, six unsymmetrical bisquaternary compounds containing large lipophilic groups were compared for their ability to inhibit phenylacetate hydrolysis and the reaction of the enzyme with GD. These compounds failed to provide favorable differences; the principle, however, is important. Acetylcholinesterase is an allosteric enzyme. In time, allosteric perturbers should be found which will provide the means for selective control of the enzyme's biologically critical reactions. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 1974
- Accession Number
- AD0778159
Entities
People
- George M. Steinberg
- Joyce Cramer