Effects of Coronary Hypotension and Endotoxin on Myocardial Performance.
Abstract
The purpose of the study was to explore the separate roles of aortic hypotension and endotoxin in the pathogenesis of heart failure. Experiments were performed on isolated canine hearts supported by blood from anesthetized animals. The first series of hearts (experimental group) was subjected to four hours of coronary hypotension plus endotoxin administered to both heart and support dog, while the second series (control group) was subjected to low pressure alone. Approximately 90% of experimental hearts and 40% of the controls demonstrated dysfunction at four hours, as evidenced by increased left ventricular end diastolic pressure at afterloads between 50 and 125 mm Hg. Negative dP/dt (-dP/dt) became less negative in experimental hearts at four hours while coronary blood flow, heart rate and oxygen uptake were elevated in relation to the control group. Findings suggest that early abnormal diastolic filling and inadequate coronary perfusion may perform significant roles in the precipitation of heart dysfunction after endotoxin. (Modified author abstract)
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 15, 1974
- Accession Number
- AD0778305
Entities
People
- J. J. Spitzer
- Lerner B. Hinshaw
- Linda T. Archer
- M. D. Peyton
- M. R. Black
Organizations
- University of Oklahoma Health Sciences Center