Oxygen Transport Changes in Canine Subjects Transfused with Stored Blood from Chronically Anemic Donors.
Abstract
Blood from the anemic dogs was stored for 14, 28 or 42 days and compared to normal stored blood. A decrease in oxygen dissociation P50 point, 2,3 diphosphoglycerate, and adenosine triphosphate occurred with storage in both sets. 2,3 diphosphoglycerate levels were slightly higher initially in anemic units and remained higher than those of the controls during storage. Transfusion of the stored blood had minimal effect on the recipient, probably because of the volume (40 ml) used. A small, but significant, increase in the P50 was observed immediately after transfusion of the anemic blood. Adenosine triphosphate levels increased significantly and remained high 24 hr after transfusion. Red cell survival decreased with storage for both normal and anemic stored units, but the decrease was not as marked with the anemic units, suggesting that the population distribution of these may have been different as compared to those of the normal units. (Modified author abstract)
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 07, 1974
- Accession Number
- AD0778730
Entities
People
- Angelo I. Zegna
- Charles E. Shields
- David E. Meixner
- Garry C. Phillips
Organizations
- United States Army Medical Research Laboratory