Lymphocytes and Yellow Fever. II. Mechanisms Involved in the Transient Virus Refractory State Following Vaccination in Man with the 17-D Strain of Yellow Fever Virus.
Abstract
Human lymphocytes stimulated with PHA are capable of supporting the replication of many viruses, including 17-D, in vitro. Lymphocytes removed from 17-D virus vaccinated human volunteers, 7-11 days following immunization, failed to support 17-D virus replication in vitro; by day 25, lymphocytes from most vaccines had regained completely their capacity to replicate 17-D virus. The results of our studies suggest that the 17-D virus refractory state may be attributable to the release of cytotoxic substances by certain lymphocytes in culture which in turn affect the ability of other cells to support virus replication. The substantiation of these results would suggest a similar mechanism for the control of viral infections by lymphocytes in vivo. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 30, 1974
- Accession Number
- AD0779500
Entities
People
- E. Frederick Wheelock
Organizations
- Thomas Jefferson University