Sequential Immunization of Spider Monkeys with Three Group B. Arboviruses: Yellow Fever, Langat, and Dengue-2.
Abstract
Four spider monkeys were sequentially vaccinated at 30-days intervals with yellow fever (17D), a Langat and a dengue type 2 attenuated strains. Four months after the last vaccination these monkeys and 4 controls which had been injected the vaccine substrates only were subcutaneously challenged with Japanese encephalitis virus. As anticipated, none of these animals developed signs of illness; viremia titrations done daily for seven consecutive days after challenge were used as a criterion for protection. No protection was detected as a result of vaccination. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 1974
- Accession Number
- AD0780125
Entities
People
- Jordi Casals-ariet
Organizations
- Yale University