Effects of Coronary Hypotension on Myocardial Substrate Utilization.
Abstract
Changes in myocardial substrate utilization were studied following experimental coronary hypotension in the isolated heart of a small dog perfused with the blood of a large donor animal. Prolonged severe hypotension caused a decreased coronary sinus blood flow and myocardial oxygen consumption as well as a relative preference of FFA oxidation and diminished lactate and glucose uptake by the myocardium. It is concluded that the changes of myocardial substrate utilization were quite different following prolonged coronary hypotension from those obtained during experimental hemorrhagic or endotoxic shock. (Modified author abstract)
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 1974
- Accession Number
- AD0780239
Entities
People
- A. A. Bechtel
- J. J. Spitzer
- L. J. Greenfield
- Linda T. Archer
- M. R. Black
Organizations
- University of Oklahoma Health Sciences Center