Distribution of Progesterone and Its Effect on Human Blood during Storage.
Abstract
Erythrocytes, preserved with addition of progesterone to whole blood, maintain higher adenosine triphosphate levels, lower spontaneous lysis, higher osmotic resistance and higher uptake of methylene blue throughout 42 days of storage when compared to red cells preserved without progesterone. The hormone appears to be in steady-state equilibrium between plasma and erythrocytes and the amount in the plasma is almost twice that present in the cells. After repeated saline extractions, about 10% of the total progesterone remains attached to the erythrocytes. Cell populations of low density (young cells) show high specific activity throughout the storage time investigated. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 29, 1974
- Accession Number
- AD0780848
Entities
People
- Frankc DeVenuto
- Sarah M. Wilson
Organizations
- United States Army Medical Research Laboratory