The Reversible Effects of Acute Adenine Toxicity in Rats.
Abstract
From this study in a large population of rats, adenine toxicity to renal tissue was found to be dose-rate related. Average transient weight loss was encountered at all levels; however, recovery by the end of 30 days was complete. It was shown that a dose level of 25 mg/kg body weitht is the only dose level at which no evidence of morphologic renal damage occurs, although a single transient rise in BUN and creatinine values took place. At higher dose levels, below the LD50, a more prolonged transient uremia and renal impairment was a consistent finding. Acute tubular necrosis was encountered initially; however, a complete morphologic recovery was documented by one week in 50 and 100 mg/kg body weight dose levels. Based on information obtained from animal models, adenine in doses less than 25 mg/kg body weight would be reasonable if renal function was normal. (Modified author abstract)
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 15, 1974
- Accession Number
- AD0781501
Entities
People
- C. E. Shields
- D. E. Endorf
- J. T. Ervin
- S. E. Levasseur
- S. M. Greenwood
Organizations
- United States Army Medical Research Laboratory