Structure-Activity Relationships on Compounds Having Neuro-Muscular Activity
Abstract
The report deals with the biological activity of four different series of compounds which were developed to clarify the structure-activity relationships required for optimal biological activity. Three of the series were carbamates with potent antiesterase activity. These three series were bis symmetrical quaternary ammonium isoquinoline carbamates, bis unsymmetrical quaternary ammonium isoquinoline carbamates, and tetra and octa quaternary ammonium isoquinoline carbamates. In the course of the study, a series of hemicholinium-like compounds was further developed and tested for both hemicholinium-like action as well as for antiesterase action. The latter are methyl pyridinio and 2 hydroxy ethyl dimethyl ammonio analogues.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 28, 1974
- Accession Number
- AD0782491
Entities
People
- Ted A. Loomis
Organizations
- University of Washington