Technetium-99m Pyrophosphate for Bone Imaging.
Abstract
Of the various 99mTc phosphates suggested for bone imaging, 99mTc pyrophosphate appears to have the desirable characteristics of commercial availability of sodium pyrophosphate and availability of analytical controls to assure the quality of the final product. Systematic variations of the parameters of the 99mTc tin pyrophosphate preparation were evaluated by gamma camera images in swine. These studies indicate that the best tissue distribution is obtained by adding 1.75 ml of 0.1 M sodium pyrophosphate at pH 10 to 0.25 ml of 1 mg/ml tin chloride followed by 1.50 ml 99mTcO4(-). In vivo organ distribution indicates the importance of normalizing doses on a per weight basis for comparative animal studies. If the proper dose of phosphate is used, 99mTc pyrophospate results in high quality bone images in animals and humans and can be easily prepared and assayed. (Modified author abstract)
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 1974
- Accession Number
- AD0782675
Entities
People
- H. Kubota
- J. S. Stevenson
- R. C. Reba
- W. C. Eckelman
Organizations
- Armed Forces Radiobiology Research Institute