Studies on the Hydrolysis and Absorption of Folic Acid Polyglutamates in Tropical Sprue.
Abstract
Studies were done on a patient in whom the hypothesis that the disease was due to folate coenzyme deficiency was studied. The patient was shown to be unable to respond to 5-methyltetrahydrofolate acid orally or parenterally, indicating that repletion of folic acid coenzymes alone is insufficient in this disease if B12 deficiency is present. The patient responded to 1 microgram of B12 with complete remission of disease. In order to clarify some of the differences and similarities between tropical sprue and the blind loop syndrome, studies were undertaken in 24 dogs, in whom various surgical blind loops were constructed. High blind loops resulted in elevation of the serum folate, but loops composed of ileum did not. Fractionation of folates produced by bacterial proliferation within the loop revealed three major and one minor component. The manor components were identified as 5-formyltetrahydrofolate, tetrahydrofolate and 5-formyltetrahydrofolate triglutamate. (Modified author abstract)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1971
- Accession Number
- AD0782782
Entities
People
- Leslie H. Bernstein
- Sidney Gutstein
- Simeon Pollack
- Simon Weiner
Organizations
- Albert Einstein College of Medicine