The Failure of Buffered 5-Hydroxytryptamine to Increase Brain Capillary Permeability to Albumin
Abstract
The effect of buffered 5-hydroxytryptamine (5-HT) on the blood-brain barrier to 125I-albumin was studied in 14 rhesus monkeys. 5-HT was introduced into the lateral ventricle by ventriculocisternal perfusion resulting in a concentration gradient in the periventricular tissue from 1 to 800 times endogenous levels. Buffered 5-HT failed to induce an increase in periventricular vascular permeability to 125I-albumin. Earlier reports to the contrary may have resulted from species differences, as well as failure to control physiologic parameters and the use of highly acidic 5-HT preparations.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 1974
- Accession Number
- AD0783022
Entities
People
- L. S. Solomon
Organizations
- Armed Forces Radiobiology Research Institute