Experimental Use of Antibiotic-Immunodepressants,
Abstract
The antibiotic-immunodepressants (dactinomycin, bruenomycin, and rubomycin) in the doses used on the guinea pigs and hamsters selected for reproduction of the allergic reactions exhibited an expressed toxic effect. Dactinomycin in doses to 30 micrograms/kg exerted an expressed immunodepressant effect. Bruneomycin in doses of 0.75 mg/kg significantly inhibited the development of allergic contact dermatitis to 2,4-dinitro-chloro-benzene, but did not protect the animals from anaphylactic shock. Rubomycin in doses of 30 mg/kg did not inhibit allergic reactions of the immediate and delayed types.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 22, 1974
- Accession Number
- AD0783925
Entities
People
- A. A. Podkolzin
- L. A. Goryanchkina
- S. F. Maksimenko
- V. A. Ado
- V. G. Akimov
Organizations
- National Air and Space Intelligence Center