Curare-Like Activity of Mono-Quaternary Salts Containing Adamantyl Residue at the Nitrogen Atom
Abstract
As shown in previous works, mono-quaternary salts of alkamine esters of benzoic and cinnamic acids types and exhibit a pronounced curare like action. A series of methiodides of alkamine esters of benzoic and cinnamic acids were synthesized, containing at the quaternary nitrogen atom a 1-adamantyl residue. The results of the analysis and the constants of the synthesized compounds are presented. The substitution of an N-methyl residue by an N-adamantyl causes a change of the substance's mechanism of action, this applying both to the benzoic acid derivatives and to the cinnamic acid derivatives. In all cases, trimethylammonium compounds induce a spastic paralysis in chicks typical for depolarizing agents, at the same time that their adamantyl analogs induced a flaccid paralysis characteristic for a nondepolarzing block.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 21, 1973
- Accession Number
- AD0784169
Entities
People
- A. P. Arendaruk
- A. P. Skoldinov
- D. G. I. Tsvetkova
- M. I. Shmaryan
- N. V. Smirnova
Organizations
- United States Army Foreign Science and Technology Center