Microprecipitation Test for the Detection of Adenovirus Antibody

Abstract

A microprecipitation test (MPT) for the detection of adenovirus antibody has been developed. The new procedure combines precipitation of virus particles with specific antibody, separation of unreacted components from the resulting electroneutral virus-antibody complexes by electrophoresis, and detection of these complexes with a protein stain. Type-specific antibody was detected in rabbit antisera but, under similar conditions, antibody in convalescent human sera reacted with adenovirus antigens of types 4 and 7. Paired sera from 57 patients with suspected adenovirus infection were examined for significant rises in antibody activity by the microprecipitation tests and by complement fixation.

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Document Details

Document Type
Technical Report
Publication Date
May 28, 1974
Accession Number
AD0784527

Entities

People

  • David M. Robinson
  • Kenneth R. Amsler
  • Neil H. Levitt
  • Robert W. Mckinney

Organizations

  • United States Army Medical Research Institute of Infectious Diseases

Tags

DTIC Thesaurus Topics

  • Adenoviruses
  • Antibodies
  • Antigens
  • Biological Sciences
  • Biomedical And Dental Materials
  • Cells
  • Chemistry
  • Detection
  • Epithelial Cells
  • Immune Serums
  • Infection
  • Medical Laboratories
  • Mixing
  • Mixtures
  • Precipitation
  • Public Health
  • Viruses

Fields of Study

  • Biology

Readers

  • Analytical Chemistry
  • Virology (or Medical Virology).