The Antiviral Effect of Some Derivatives of Tilorone HCl on TBE in White Mice

Abstract

Four derivatives of tilorone HCl were tested against tickborne encephalitis (TBE) in mice and compared with tilorone HCl. All substances induced interferon and thus protected mice against infection. The drugs were active not only after oral but also after subcutaneous and intraperitoneal application. Rather an antagonistic effect was observed when the compounds were used combined. However treatment of mice with tilorone HCl or a derivative in combination with Poly I:C enhanced survival of mice.

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Document Details

Document Type
Technical Report
Publication Date
Sep 18, 1974
Accession Number
AD0784927

Entities

People

  • Christian Kunz
  • H. Dippe
  • Hanns Hofmann

Organizations

  • United States Army Medical Research Institute of Infectious Diseases

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Biological Sciences
  • Biomedical Research
  • Commerce
  • Diseases And Disorders
  • Inductors
  • Infection
  • Interferon
  • Materials
  • Mouth Diseases
  • Proteins
  • Specialty Uses Of Chemicals
  • Time Intervals
  • Universities
  • Viruses
  • Wound Infections

Fields of Study

  • Biology
  • Medicine

Readers

  • Virology (or Medical Virology).