Response of the Edematous Isolated Lung to Static Positive End-Expiratory Pressure.
Abstract
Positive end-expiratory pressure (PEEP) has been demonstrated to improve systemic arterial oxygenation in respiratory distress secondary to interstitially edematous lung. Clinical improvements, however, may be limited by the adverse circulatory effects of PEEP impairing venous return and reducing cardiac output. In an effort to eliminate this variable experimentally, the effects of graded levels of PEEP in the isolated canine lung made edematous by venous constriction were studied. These observations suggested that the increased mean inflation pressures of PEEP do not facilitate mobilization of interstitial fluid nor improve lung mechanics and that the observed improvement in gas exchange probably relateds to inflation of previously collapsed alveoli. In clinical use, however, PEEP is applied at one level for a prolonged period of time. Therefore, to delineate the prolonged effects of static PEEP, isolated canine lungs made edematous by venous constriction were treated with various levels of PEEP and observed for four hours or until hemorrhagic deterioration occurred.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 24, 1974
- Accession Number
- AD0785018
Entities
People
- J. J. Coalson
- L. H. Altshuler
- M. D. Peyton
- P. P. Brown
- R. C. Elkins
Organizations
- University of Oklahoma Health Sciences Center