Preliminary Assessment of Relative Toxicity of Several Pesticide Compounds in Behavioral Screening Tests.
Abstract
Four pesticide compounds were tested for detrimental effects on the behavior of rats trained to avoid electric shock in a modified shuttlebox procedure. ED50 values ('effective dose' for producing nonresponse in 50 percent of the subjects) were determined for Mobam, Abate, Malathion and ENT-27699. The following ED50 values were determined in this test situation: Malathion, tested at 30 minutes post-injection, 550 mg/kg; Abate, tested 1 hour post-injection, 500 mg/kg; ENT-27699, tested 1 hour post-injection, 1000 mg/kg; Mobam, tested 15 minutes post-injection, 10 mg/kg. Control subjects injected with cornoil or with isotonic saline showed no dose-response effect in this test situation, i.e., they successfully avoided the electric shock by responding during the preshock tone. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1974
- Accession Number
- AD0786519
Entities
People
- William M. Smith Jr
Organizations
- United States Army Medical Command