Histamine Formation and Histamine Liberation in Traumatic Shock and Shock Resistance,
Abstract
It was found that the liberation of vasoactive substances capable of increasing capillary permeability increases significantly in traumatic shock (Noble-Collip drum test), directly upon the effect of the traumatic stress. Between 1 and 6 hours following the effect, histamine formation increases considerably, not only locally but over the entire organism. This is the result of increased 1-histidine decarboxylase activity. In animals adapted to trauma, in the state of specific and nonspecific resistance, the increased liberation of vasoactive substances and the increased formation of histamine does not occur after the traumatic shock. The same thing applies after the prior injection of serum from trauma-adapted animals. The authors found that a humoral factor, the earlier reported adaptation factor, resistine is responsible for the inhibition of histamine liberation and formation.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 19, 1974
- Accession Number
- AD0786973
Entities
People
- A. Gecse
- G. Horpacsy
- I. Karady
Organizations
- National Air and Space Intelligence Center