Biochemical Aspects of Morphine Tolerance and Physical Dependence.
Abstract
The specific binding of narcotic agonist and antagonist to brain tissue can be studied in vitro using tritium-labeled compounds. Conditions necessary to study the specific binding which are relevant to the drug-receptor interactions are specified. Remarkable similarities exist between the specific binding observed in vitro and opiate binding to their receptor observed in vivo. Changes in macromolecules involved in the specific binding are currently under investigation. The data indicated that there are no remarkable differences in development of physical dependence on morphine due to the difference in age of subjects. The development of tolerance, however, was clearly influenced by the age of the subject: younger animals developed tolerance more rapidly than older animals when both groups of animals were injected repeatedly with equal doses (mg/kg) or equipotent doses of morphine. (Modified author abstract)
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1974
- Accession Number
- AD0787133
Entities
People
- Theodore M. Brody
Organizations
- Michigan State University