EFFECTS OF BETA-RADIATION ON THE INTERMEDIARY METABOLISM OF MAMMALIAN SKIN.
Abstract
This project was initiated with the specific objective of determining whether radiation interfers with the availability of chemical energy since Swann had proposed that the filling of an energy reservoir was necessary before mitosis occurred and the biosynthesis of DNA and RNA were energy-requiring processes. The following three possible mechanisms for such a radiation effect were considered: (1) the high-energy compounds themselves (e.g. adenosine triphosphate (ATP), uridine triphosphate (UTP), acyl thioesters, etc.) might be destroyed; (2) there might be a decrease in the rate of synthesis of such energy-rich compounds and (3) there might be an alteration in the pathways of carbon metabolism which per se, would result in the conservation of less energy in usable chemical form.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 30, 1966
- Accession Number
- AD0800188
Entities
People
- I. A. Bernstein
Organizations
- University of Michigan