CHEMICAL STUDIES IN CONNECTION WITH POTENTIAL SYSTEMIC INSECT-REPELLENTS AND PROPHYLACTIC AGENTS DEPOSITED IN THE SKIN
Abstract
The subject investigation constitutes a continuation of the previous studies directed toward the development of reliable prophylactic agents against pathogenic or physical impairments inflicted through the skin. While experimental design encompasses studies which are anticipated to yield information for the development of moieties possessing keratinization-enhancing, sunlight-induced-erythemogenesis-preventing, antidermatophytic and antibacterial properties, the primary targets are dependable and safe agents with long-lasting insect-repellent efficacy. In order to accomplish the objectives set forth above, studies were undertaken on the structural requirements and physicochemical characteristics associated with a compound's capacity (a) for anchoring to dermal tissue constituents following its topical administration, and/or (b) for enhancing its localization in dermal tissue following its parenteral, and even peroral, administration. An attempt was made to integrate either of these, with molecular features known to possess insect-repellency, into new hybrid molecules. These new synthetic moieties would be expected to be long-lasting insect-repellent agents whether they be applied topically or administered systemically.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 31, 1966
- Accession Number
- AD0804178
Entities
People
- A. Lasslo
- R. P. Quintana
Organizations
- University of Tennessee