THE LOCAL EFFECT OF SEROTONIN UPON RENAL VASCULAR RESISTANCE AND URINE FLOW RATE,
Abstract
An attempt was made to study the renal vascular resistance and urine flow changes upon infusion of serotonin into the renal artery of the dogy. Serotonin was infused into the renal artery of 37 dogs at 10 and 100 micro gm/min. The kidneys were studied with intact renal nerves, after denervation, and following denervation plus infusion of phentolamine. Blood flow rate was controlled and uncontrolled. Renal vascular resistance increased, on the average, 23% above the control level in the nerve intact and denervated kidneys and about half this amount in the denervated kidneys infused with phentolamine. Significant changes in urine flow rate were not observed. Gross and microscopic examination of the kidneys revealed no specific pathological lesions. The local effect of serotonin when infused into the renal artery of the dog is a moderate active increase in renal vascular resistance through some mechanism unrelated to extrinsic nerves and circulating or locally released catecholamines. Regular changes in urine flow rate were not observed and the antidiuresis reported by others following systemic administration must result from indirect action on the kidney. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 06, 1958
- Accession Number
- AD0806439
Entities
People
- D. A. Emanuel
- F. J. Haddy
- Joseph K. Scott
- R. Collins
Organizations
- United States Army Medical Research Laboratory