THE INFLUENCE OF IRRADIATION ON NEISSERIA MENINGITIDIS L-FORM INFECTION IN MICE.

Abstract

The pathogenicity of a strain of Neisseria meningitidis derived from a reverted L-form is compared with its parent bacterium. Both strains produced lethal infections in mice but 20 micrograms of penicillin failed to uniformly protect mice against death due to the reverted strain as it did with the parent strain. Total body irradiation increased the fatality rates and prolonged the bacteremias following infection with both strains. Autopsy cultures failed to yield either organism after recovery from bacteremia. Irradiation of mice after recovery from infection with both strains failed to induce recurrent bacteremia. Stabilization of the L-form occurred during these studies, and stable L-forms were found to persist in the tissue of normal mice for at least 5 days. (Author)

Document Details

Document Type
Technical Report
Publication Date
Jan 30, 1967
Accession Number
AD0806604

Entities

People

  • Malcolm I. Page

Tags

DTIC Thesaurus Topics

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Bacteremia
  • Bacterial Infections And Mycoses
  • Death
  • Diseases And Disorders
  • Fatalities
  • Infection
  • Radiation
  • Recovery
  • Wound Infections

Fields of Study

  • Biology

Readers

  • Microbial Pathology
  • Molecular Biology and Genetics