RECOMBINATION AND TRANSMISSION STUDIES WITH INFLUENZA VIRUS.
Abstract
Transmission of influenza virus infection in mice can be correlated with demonstrable airborne virus in the vicinity of infector mice during the period of their infectiousness; the critical difference that distinguishes transmissible and non-transmissible strains of virus has been identified as a difference in the release of the viruses from the infector mouse into his environment. The genetic studies have established beyond doubt, through biochemical analysis of hybrid viruses, that immunizing antigens of widely different viruses can be recombined in stable form through genetic interaction of such viruses. Furthermore, it has been shown that one such antigen may be the neuraminidase of the virus particle and that this antigen differs from the hemagglutinin of the virus. These findings have opened the door to better definition of the role of the neuraminidase enzyme in infection and in immunity. In studies in mice it has been shown that influenza virus antigenic hybrids produced by sequential back-crosses may have progressively increased broader immunizing capacity.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 31, 1966
- Accession Number
- AD0807635
Entities
People
- Edwin D. Kilbourne
Organizations
- Weill Cornell Medicine