SUPPRESSION OF VIRULENCE IN PASTEURELLA PESTIS BY THE EPISOME F-LAC

Abstract

The episome F-lac was transferred from Escherichia coli F-lac into virulent strains of Pasteurella pestis. The resulting strains of P. pestis F-lac were avirulent in mice but segregated clones that were fully virulent. This suppression of virulence by F-lac was correlated with a concomitant suppression of the calcium requirement, which is known to be associated with virulence in P. pestis.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1967
Accession Number
AD0808017

Entities

People

  • Michael J. Surgalla
  • Robert M. Zsigray
  • William D. Lawton

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Amino Acids
  • Animals
  • Anti-Bacterial Agents
  • Bacteria
  • Bacteriology
  • Biological Sciences
  • Cells
  • Culture Media
  • Escherichia
  • Escherichia Coli
  • Gammaproteobacteria
  • Laboratory Animals
  • Maryland
  • Microorganisms
  • Plasmids
  • Production

Fields of Study

  • Biology

Readers

  • Microbial Pathology
  • Molecular Genetics