A CLINICOPATHOLOGIC STUDY OF THE EFFECTS OF RIOT CONTROL AGENTS ON MONKEYS V. LOW CONCENTRATIONS OF DIPHENYLAMINO- CHLOROARSINE (DM) OR O- CHLOROBENZYLIDENE MALONONITRILE (CS) FOR EXTENDED PERIODS
Abstract
This is a report of the order, severity, and resolution of pathologic changes in Macaca mulatta monkeys exposed to low concentrations of DM or CS for extended periods. The following observations were made: (1) Exposure of the monkeys to low concentrations of CS for relatively long periods (Ct, 265 to 9120 mg min/cu m; t, 5 to 30 min) produced few clinical signs, no systemic manifestations of toxicity, and no pathologic changes. (2) Exposure of the monkeys to low concentrations of DM for relatively long periods (Ct, 198 to 13, 2000; t, 2 to 60) produced clinical signs and pathologic changes in a significant number of the animals. The clincial signs were primarily nausea and vomiting, and the pathologic changes were bronchorrhea, congestion, edema, and pulmonary inflammation.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1967
- Accession Number
- AD0808731
Entities
People
- C. S. Streett
- D. F. Ford
- D. R. Helland
- G. E. Striker
- L. H. Herman