PATHOPHYSIOLOGICAL AND BIOCHEMICAL CHANGES IN ANTHRAX

Abstract

Pathophysiological and biochemical changes in anthrax are reviewed. The comparison between spore- and toxin-challenged animals shows a remarkable similarity, indicating that the toxin of Bacillus anthracis caused death although the organisms per se caused little pathophysiological response. Death was primarily due to a respiratory depression of central nervous system origin; the cardiovascular system remained intact. Death occurred with an extreme anoxia that was accompanied late in the disease by numerous secondary or nonspecific changes in the blood cellular, chemical, and gaseous elements.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 1967
Accession Number
AD0811760

Entities

People

  • Frederick Klein
  • Jerry S. Walker
  • Ralph E. Lincoln

Tags

DTIC Thesaurus Topics

  • Acid-Base Imbalance
  • Animals
  • Arteries
  • Blood
  • Blood Cells
  • Brain
  • Cardiovascular Diseases
  • Cardiovascular Physiological Phenomena
  • Cardiovascular System
  • Cells
  • Central Nervous System
  • Death
  • Depression
  • Infectious Diseases
  • Nervous System
  • Reticuloendothelial System
  • Rhesus Monkeys

Fields of Study

  • Environmental science
  • Medicine

Readers

  • Cardiovascular Physiology
  • Microbial Pathology