INACTIVATION OF VENEZUELAN EQUINE ENCEPHALOMYELITIS VIRUS BY GAMMA RADIATION

Abstract

Exposure of Venezuelan equine encephalomyelitis (VEE) virus at -70 C to 6,000,000 r gamma radiation (Co60) resulted in loss of lethality for young adult mice and guinea pigs and loss of capacity to produce plaques or cytopathic effects in tissue culture. The suckling mouse was more sensitive for detecting live virus in irradiated suspensions than the adult mouse or guinea pig. Live virus was demonstrable in preparations exposed to 6,000,000 r but not in suspensions exposed to 8,000,000 r or more. The rate of inactivation of VEE virus by gamma radiation was an exponential function of the dosage.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 1967
Accession Number
AD0813231

Entities

People

  • Henry R. Tribble Jr.
  • Morton Reitman

Tags

DTIC Thesaurus Topics

  • Animals
  • Arbovirus Infections
  • Cells
  • Equine Encephalitis
  • Exponential Functions
  • Gamma Rays
  • Ionizing Radiation
  • Laboratory Animals
  • Materials
  • Radiation
  • Rodents
  • Survival
  • Tissue Culture
  • Venezuelan Equine Encephalomyelitis
  • Viruses

Fields of Study

  • Biology

Readers

  • Nuclear and Radiation Engineering.
  • Virology (or Medical Virology).