ANTIGENIC STRUCTURE OF THE TOXINS OF CL. BOTULINUM TYPE C ISOLATED IN THE USSR
Abstract
Strains of Cl. botulinum type C, which were isolated from minks in the USSR, belong to subtype C beta. The strain of Cl. botulinum type C No 91, which is used in the production of medicinal and diagnostic antibotulinum sera, and also toxoids, belongs to subtype C alpha. Botulinum toxins of types C alpha, C beta, and D consist of 3 toxin components -- C alpha, C beta, and D, but in each of them the main component prevails in a quantitative respect. The remaining two are found in considerably lesser quantities. Due to the presence of common antigens in the toxins, a cross neutralization reaction is observed between the botulinum sera and the toxins of types C alpha, C beta, and D. For the correct identification of botulism causative agents, isolated from various objects (soil, patients, corpses, etc.) it is necessary that the series of diagnostic antitoxic antibotulinum type specific sera include sera of types C beta and D on a level with sera of types A, B, C, and E.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 1966
- Accession Number
- AD0815201
Entities
People
- K. I. Matveyev
- T. I. Bulatova
Organizations
- United States Army Biological Warfare Laboratories