QUANTITATIVE ASSESSMENT OF PHAGOCYTOSIS BY MACROPHAGES IN VITRO OF ANTHRAX BACILLI OF DIFFERENT VIRULENCE. REPORT 2. THE RESULTS OF QUANTITATIVE CALCULATIONS
Abstract
As a result of the measurements and calculations which were performed, it was established that there were certain peculiarities in the growth and multiplication of bacteria of the STI-1 and Tsenkovskiy 71/12 strains in the presence of normal and immune macrophages. The quantitative evaluation of the results of the tests did not expose any advantage of immune macrophages over normal based on the intensity of phagocytosis, however, in the presence of immune cells there was a more noticeable inhibition of growth of bacteria of both types of strains. The preliminary quantitative results make it possible to propose that immune and normal macrophages of guinea pigs 'attack' the bacteria of avirulent and virulent anthrax strains with practically the same activity. This fluctuated within the limits of 35--50 cells per 1 mm. The method of calculations which was developed made it possible to obtain data which objectively characterizes the process of phagocytosis and its dynamic development.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 1966
- Accession Number
- AD0815238
Entities
People
- N. N. Ginsburg
- T. N. Maslova
Organizations
- United States Army Biological Warfare Laboratories