PHARMACOLOGICAL AND BIOCHEMICAL CHANGES IN ANIMALS MADE AGGRESSIVE BY ISOLATION.
Abstract
A large number of psychoactive drugs were tested on the aggressiveness induced by isolation; till now only ampizine, chlordiazepoxide and its derivatives have shown a certain degree of effectiveness. In aggressive animals the level of 5-hydroxyindolacetic acid was found to be consistently lower than in the controls while the turnover rates of serotonin and noradrenalin were found to increase. However, brain serotonin turnover could not be used to predict whether a strain of mice would or would not develop aggressiveness upon isolation. In addition in female mice, which consistently do not become aggressive after isolation, serotonin turnover rates were found to be higher than the turnover rates of the males of the same strain which do develop isolation aggressiveness. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 1967
- Accession Number
- AD0818421
Entities
People
- E. Dolfini
- E. Giacalone
- L. Valzelli
- Silvio Garattini
Organizations
- Mario Negri Institute for Pharmacological Research