RECOMBINATION AND TRANSMISSION STUDIES WITH INFLUENZA VIRUS.
Abstract
A combined genetic, biochemical and experimental epidemiological approach to the problems of influenza virus variation in structure have been continued. Evidence continues to accrue that the neuraminidase enzyme of the virus is an important factor in transmission of influenza virus infection in a mouse model. In other studies, this model has proved to be useful in testing of chemoprophylactic agents for influenza. Genetic studies of influenza viruses have demonstrated that recombinants of equine and human influenza viruses can be produced in the laboratory and that one such recombinant is antigenically hybride-possessing antigens derived from both human and equine parents. The production of viral recombinants has facilitated the isolation of the neuraminidase enzyme and the production of specific antiserum to it. Biochemical analysis of influenza virus has also been facilitated by the deliberate design of recombinants that are more amenable to biochemical analysis. From these studies it is anticipated that basic information concerning influenza virus structure and variation will be obtained. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 1967
- Accession Number
- AD0819107
Entities
People
- Edwin D. Kilbourne
Organizations
- Weill Cornell Medicine