PHARMACOLOGIC STUDIES.
Abstract
The principal object of these investigations was to determine the physicochemical properties of hexafluoroisopropyl methyl ether, an anesthetic. Considering that anesthesia and the convulsive seizure encompass the complete spectrum of central nervous system activity, these two agents serve as excellent means to obtain a clue concerning these phases of cerebral activity: Hexafluorodiethyl ether (Indoklon) and its Isomer (ISO): The pharmacologic antagonism between the isomers is striking. It appears that each isomer is competing for its respective receptor site, namely, the convulsive or anesthetic site. The Effect of Inert Fluorinated Agents on Fluroxene Experiments with two inert fluorinated agents, fluoroform and Freon E-1, suggest the hypothesis that the convulsive fluorinated ethers like flurothyl evoke a twofold response: seizures and anesthesia; with flurothyl, the former action greatly preponderates. Metabolism of Ether and Chloroform: The absence of deuterium exchange from deutero ether suggests that the anesthetic action of either is not dependent upon atomic exchange of ether with other molecules in the biological system. It suggests that the syndrome is evoked by the intact molecule. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 24, 1967
- Accession Number
- AD0822662
Entities
People
- John C. Krantz Jr