THE EFFECT OF RAPID CHANGE IN THERMAL ENVIRONMENT ON ABILITY OF HUMAN BLOOD TO ACETYLATE AROMATIC AMINES AND TO INCORPORATE ACETATE-1-C14 INTO LIPIDS.
Abstract
Exposure of normal subjects to heat (37C) or cold (4-6C) resulted in changes in the incorporation of acetate-1-C14 into the blood lipids in vitro. Exposure to heat resulted in decreased incorporation and the converse occurred on exposure to cold. No significant difference was found in the responses of a small series of heat acclimated subjects on exposure to heat or cold as compared to paired non-acclimated subjects. However, there was a higher initial incorporation in 4 out of 5 heat acclimated subjects as compared to their non-acclimated controls. Addition of epinerphrine or norepinephrine to whole blood in vitro decreased incorporation of acetate-1-C14 into lipids, while addition of insulin increased incorporation. Addition of triiodothyronine had no consistent effect. Insulin stimulated incorporation of acetate into lipids in blood of diabetic subjects to a lesser extent than in the blood of normal subjects. Removal of plasma resulted in increased incorporation of acetate into lipids. The stimulatory effect of insulin on incorporation was also inhibited by the presence of plasma. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1967
- Accession Number
- AD0825248
Entities
People
- Nathan A. Kaufmann
- S. H. Blondheim
Organizations
- Hebrew University of Jerusalem