THE ALTERATION OF VISUAL PERCEPTUAL MECHANISMS BY CHEMICAL AGENTS.
Abstract
Cats with electrodes chronically implanted in cortical, subcortical and rhinencephalic structures of the brain were conditioned to press one of three panels for positive reinforcement. The visual conditioned stimulus (CS) was presented at 10 cps in three paradigms: (1) selection of the single lighted panel (light-dark discrimination); (2) discrimination between similar patterns presented at differing intensities (total luminous flux discrimination); and (3) discrimination between two differing geometric patterns of similar intensity. The CS figures were pulsed to allow frequency labeling of brain bioelectric activity. This activity was collected during habituation to the conditioning stimulus, during training and during stabilized performance of the behavior. Atropine sulfate (0.25-1 mg/kg), LSD-25 (25-100 mcg/kg), chlorpromazine (1-5 mg/kg) and trifluoperazine (0.5-2 mg/kg) altered performance and associated EEG responses to the CS differently depending upon the paradigm. The bioelectric data were examined for changes associated with the behavioral state with the aid of a LINC computer using the following treatments: averaging, autocorrelation, cross correlation, autospectra, period analysis, and a variety of pattern recognition schemes. The data indicate that there are recognizable changes associated with the level of training and the correctness of performance, as well with pharmacological alteration of behavior. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1967
- Accession Number
- AD0825760
Entities
People
- Keith F. Killam Jr
Organizations
- Stanford University