ALPHA-1 GLOBULINS IN THOSE SUSCEPTIBLE TO VIRAL ACUTE RESPIRATORY DISEASES
Abstract
The respiratory disease pattern observed in two companies of naval recruits during a 1959-1960 (Fall-Winter and Summer) epidemiological survey indicated an average of more than 2 discrete respiratory episodes per man. Over 50% demonstrated antibody responses to multiple antigens, while only 15.6% failed to show a serological rise to a viral respiratory antigen. Most of the infections were acquired during the first half of the training period. There were 2 distinct peaks of clinical disease. The first occurred the 10th day of training, and the second on the 25th day. The peaks of clinical disease were followed on both instances by serological peaks 10 days later. The alpha-1 globulin values were found to be significantly elevated in 40% of the recruits who subsequently demonstrated multiple serological responses. Seventy-five percent of the recruits considered to be susceptibles on the basis of demonstrating more than 2 discrete respiratory episodes had significantly elevated initial serum alpha-1 globulin levels. A highly significant relationship (p = <0.001) was found between number of discrete episodes and the alpha-1 globulin levels. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 11, 1967
- Accession Number
- AD0825979
Entities
People
- M. J. Mcnamara
- R. I. Lytle