PHARMACOLOGY AND METABOLISM OF HYBALINE A

Abstract

Toxicologic studies are described in which Hybaline A (an aluminum borohydride derivative) has been administered to rats, rabbits, cats, and dogs via the intragastric, intraperitoneal, intravascular, cutaneous, subcutaneous, and inhalation routes. All available data indicate that all effects of Hybaline A on mammalian systems can be attributed to physiochemical changes caused by energy production during hydrolysis or thermal decomposition of Hybaline A. No circulating metabolites of Hybaline A were identified. Those animals that survived the initial exposure showed no changes in any system that can be considered a pharmacodynamic action of Hybaline A.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 1967
Accession Number
AD0830838

Entities

People

  • Myron S. Weinberg
  • Richard E. Goldhamer

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Air Force
  • Air Force Facilities
  • Arteries
  • Biomedical Research
  • Blood
  • Chemistry
  • Clinical Laboratories
  • Corporations
  • Export Controls
  • Government (Foreign)
  • Governments
  • Materials
  • Materials Laboratories
  • Medical Laboratories
  • New York
  • Organic Materials
  • United States

Fields of Study

  • Chemistry

Readers

  • Military Engineering.
  • Organic Chemistry
  • Toxicology/Environmental Toxicology