INDUCTION OF INTERFERON BY COXIELLA BURNETII IN CELL CULTURES

Abstract

The selective induction of interferon in McCoy and L cell cultures by Coxiella burnetti is described. Test preparations, assayed in homologous cell cultures, showed that significant amounts of interferon were produced from McCoy cells in the absence of rickettsial multiplication. In contrast, no measurable amounts of interferon were produced from L cells that supported rickettsial multiplication. Rickettsial interferon possessed biological and physical properties similar to those ascribed to viral interferon.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 1968
Accession Number
AD0833203

Entities

People

  • Edmund H. Kozikowski
  • Nicholas Hahon

Tags

DTIC Thesaurus Topics

  • Animal Diseases
  • Biological Factors
  • Cell Line
  • Cells
  • Contrast
  • Culture Techniques
  • Dilution
  • Fibroblasts
  • Inhibitors
  • Physical Properties
  • Production
  • Proteins
  • Q Fever
  • Tissue Culture
  • United States
  • Viruses
  • Yellow Fever

Fields of Study

  • Medicine

Readers

  • Infectious Disease/Epidemiology
  • Microbial Pathology
  • Molecular Biology and Genetics